TB-500 is often described online as a copy of thymosin beta-4. In fact it is a tiny piece of it. This guide explains the difference and what the research on each molecule really shows.
Thymosin beta-4 is a natural protein of 43 amino acids found inside almost every cell. Its main known job is to hold on to actin, the protein that forms the cell's internal scaffolding, so that cells can change shape and move. Scientists have studied it for decades as a possible aid to wound, eye and heart repair.
TB-500 is something different: a lab-made peptide of only seven amino acids, LKKTETQ, with an acetyl group added to one end. This stretch matches the part of thymosin beta-4 that binds actin. It first came to wide attention as a veterinary product in horse racing, where laboratories developed tests to catch its use.
Much of what is written about TB-500 is really about the full protein. The pages here keep the two apart, say which molecule each study used, and link to the sources.
| Name | TB-500 (N-acetyl-LKKTETQ) |
| Size | 7 amino acids, molecular weight about 889 |
| Formula | C38H68N10O14 |
| Parent protein | Thymosin beta-4, 43 amino acids, about 4.9 kDa |
| Region copied | Residues 17 to 23 of thymosin beta-4, the actin-binding site |
| Human data | No published clinical trials of TB-500 itself; several trials of full thymosin beta-4 |
| Regulatory status | Not authorised as a medicine; prohibited by WADA under S2 |
Nothing on TB-500.info is medical or veterinary advice. TB-500 sold as a research chemical is not meant for people or animals. If you are dealing with an injury, speak to a qualified professional.
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